Keywords:
hepatocellular carcinoma, hepatitis B, hepatitis C, comparative study, Cotonou
Abstract
Introduction: The burden of hepatocellular carcinoma (HCC) remains high in developing countries. This study compared HCC associated with hepatitis B virus (HBV) and hepatitis C virus (HCV) in Cotonou.
Methods: This was a retrospective, cross-sectional analysis from January 2014 to December 2020. All cases of HCC due to HBV or HCV identified by the Cotonou Cancer Registry were included.
Results: A total of 91 cases of HCC were included, 79.1% associated with HBV and 20.9% with HCV. The mean age was 52.3 years. Mortality was 100%, with a mean survival time of 63.9 days. Male gender predominated with a M:F ratio of 2.5:1. HBV-associated HCC patients were younger than the HCV-associated group (mean age 51.4 vs. 55.7 years; p = 0.01). There was no difference regarding education (p = 0.05), religion (p = 0.44), alcohol or tobacco consumption (p = 0.59), or physical activity (p = 0.99).
Conclusion: HBV-associated HCC predominated with patients in this group younger when compared to the HCV group. The outcome was universally fatal, with no patients surviving.
Author Biographies
AR Kpossou, University of Abomey-Calavi
Faculty of Health Sciences, University of Abomey-Calavi and Clinique Universitaire d’Hépato-Gastroentérologie, Centre National Hospitalier Universitaire Hubert Koutoukou Maga, Benin
FHR Gnangnon, University of Abomey-Calavi
Faculty of Health Sciences, University of Abomey-Calavi and Cotonou Cancer Registry, National Programme Against Noncommunicable Diseases, Ministry of Health and University Visceral Surgery Clinic, Centre National Hospitalier Universitaire Hubert Koutoukou Maga, Benin
K N’Tcha, University of Abomey-Calavi
Faculty of Health Sciences, University of Abomey-Calavi, Benin
C Toumé, Cotonou Cancer Registry
Cotonou Cancer Registry, National Programme Against Noncommunicable Diseases, Ministry of Health, Benin
SA Amidou, Cotonou Cancer Registry
Cotonou Cancer Registry, National Programme Against Noncommunicable Diseases, Ministry of Health and Laboratory of Chronic and Neurological Diseases Epidemiology, Faculty of Health Sciences, University of Abomey-Calavi, Benin
CNM Sokpon, University of Abomey-Calavi
Faculty of Health Sciences, University of Abomey-Calavi and Clinique Universitaire d’Hépato-Gastroentérologie, Centre National Hospitalier Universitaire Hubert Koutoukou Maga, Benin
RK Vignon, University of Abomey-Calavi
Faculty of Health Sciences, University of Abomey-Calavi and Clinique Universitaire d’Hépato-Gastroentérologie, Centre National Hospitalier Universitaire Hubert Koutoukou Maga, Benin
DG Gbessi, University of Abomey-Calavi
Faculty of Health Sciences, University of Abomey-Calavi and University Visceral Surgery Clinic, Centre National Hospitalier Universitaire Hubert Koutoukou Maga, Benin
N Kodjoh, Clinique de la Marina
Clinique de la Marina, Cotonou, Benin
J Séhonou, University of Abomey-Calavi
Faculty of Health Sciences, University of Abomey-Calavi and Clinique Universitaire d’Hépato-Gastroentérologie, Centre National Hospitalier Universitaire Hubert Koutoukou Maga, Benin
